Drug interactions
Lonafarnib + Valproic acid
Severity: Minor
Lonafarnib and Valproic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A substrate, but valproate is not a notable CYP3A inhibitor, so a clinically significant increase in lonafarnib is not expected. Both drugs may cause gastrointestinal effects and other adverse reactions that need monitoring.
What this interaction means in plain words
Lonafarnib and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lonafarnib belongs to Miscellaneous; Valproic acid belongs to Central Nervous System.
Why it happens
No established mechanism; valproate has little effect on CYP3A4.
What to do
No dose adjustment is needed. Monitor for lonafarnib adverse effects including gastrointestinal toxicity and liver tests.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Lonafarnib with Valproic acid?
MediHelp rates the interaction as minor. Lonafarnib and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lonafarnib is a sensitive CYP3A substrate, but valproate is not a notable CYP3A inhibitor, so a clinically significant increase in lonafarnib is not expected. Both drugs may cause gastrointestinal effects and other adverse reactions that need monitoring.
How serious is the interaction between Lonafarnib and Valproic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for lonafarnib adverse effects including gastrointestinal toxicity and liver tests.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
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