Drug interactions
Loperamide + Nicardipine
Severity: Minor
Loperamide and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine inhibits P-glycoprotein and CYP3A4 in vitro and may raise loperamide exposure. The effect is probably modest at standard doses but could increase opioid and cardiac effects of loperamide.
What this interaction means in plain words
Loperamide and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Loperamide belongs to Gastrointestinal Tract; Nicardipine belongs to Cardiovascular.
Why it happens
Inhibition of P-glycoprotein efflux and CYP3A4 metabolism of loperamide.
What to do
Use loperamide at labeled doses and watch for excess sedation, constipation or palpitations. Avoid high-dose loperamide.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Loperamide and Nicardipine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Loperamide
Other interactions of Nicardipine
Frequently asked questions
Can I take Loperamide with Nicardipine?
MediHelp rates the interaction as minor. Loperamide and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine inhibits P-glycoprotein and CYP3A4 in vitro and may raise loperamide exposure. The effect is probably modest at standard doses but could increase opioid and cardiac effects of loperamide.
How serious is the interaction between Loperamide and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use loperamide at labeled doses and watch for excess sedation, constipation or palpitations. Avoid high-dose loperamide.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
