Drug interactions
Loperamide + Sertraline
Severity: Moderate
Loperamide and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline carries a small risk of QT prolongation and mildly inhibits P-glycoprotein and CYP enzymes. With high-dose loperamide the arrhythmia risk may increase.
What this interaction means in plain words
Loperamide and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Loperamide belongs to Gastrointestinal Tract; Sertraline belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with possible weak inhibition of loperamide efflux.
What to do
Keep loperamide at labeled doses. Check an ECG and electrolytes in patients with cardiac disease or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loperamide
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Loperamide with Sertraline?
MediHelp rates the interaction as moderate. Loperamide and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sertraline carries a small risk of QT prolongation and mildly inhibits P-glycoprotein and CYP enzymes. With high-dose loperamide the arrhythmia risk may increase.
How serious is the interaction between Loperamide and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep loperamide at labeled doses. Check an ECG and electrolytes in patients with cardiac disease or other QT-prolonging drugs.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
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