Drug interactions
Loperamide + Simvastatin
Severity: Minor
Loperamide and Simvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Simvastatin might weakly inhibit P-glycoprotein and raise loperamide exposure, but a clinically important effect is unlikely at usual doses.
What this interaction means in plain words
Loperamide and Simvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Loperamide belongs to Gastrointestinal Tract; Simvastatin belongs to Cardiovascular.
Why it happens
Possible weak P-glycoprotein inhibition reducing loperamide efflux.
What to do
No routine action is needed; use loperamide at labeled doses. Watch for excess constipation or sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loperamide
Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Frequently asked questions
Can I take Loperamide with Simvastatin?
MediHelp rates the interaction as minor. Loperamide and Simvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Simvastatin might weakly inhibit P-glycoprotein and raise loperamide exposure, but a clinically important effect is unlikely at usual doses.
How serious is the interaction between Loperamide and Simvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; use loperamide at labeled doses. Watch for excess constipation or sedation.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
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