Drug interactions
Lopinavir + Metformin-pioglitazone
Severity: Moderate
Lopinavir and Metformin-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors are associated with insulin resistance and hyperglycemia, which can reduce the effectiveness of metformin and pioglitazone. Lopinavir/ritonavir may also affect pioglitazone exposure through enzyme effects.
What this interaction means in plain words
Lopinavir and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lopinavir belongs to Anti Virals; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Protease inhibitor induced insulin resistance and impaired glucose handling antagonizes antidiabetic therapy.
What to do
Monitor blood glucose and HbA1c after starting lopinavir, and intensify antidiabetic therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-pioglitazone
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Metformin-pioglitazone?
MediHelp rates the interaction as moderate. Lopinavir and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protease inhibitors are associated with insulin resistance and hyperglycemia, which can reduce the effectiveness of metformin and pioglitazone. Lopinavir/ritonavir may also affect pioglitazone exposure through enzyme effects.
How serious is the interaction between Lopinavir and Metformin-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting lopinavir, and intensify antidiabetic therapy if needed.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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