Drug interactions
Lopinavir + Nateglinide
Severity: Moderate
Lopinavir and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir, given with ritonavir, can induce insulin resistance and hyperglycemia. This may reduce the glucose-lowering efficacy of nateglinide.
What this interaction means in plain words
Lopinavir and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lopinavir belongs to Anti Virals; Nateglinide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through protease inhibitor-associated insulin resistance.
What to do
Monitor blood glucose when lopinavir/ritonavir is started or stopped. Adjust the nateglinide dose or add other therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Nateglinide?
MediHelp rates the interaction as moderate. Lopinavir and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir, given with ritonavir, can induce insulin resistance and hyperglycemia. This may reduce the glucose-lowering efficacy of nateglinide.
How serious is the interaction between Lopinavir and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when lopinavir/ritonavir is started or stopped. Adjust the nateglinide dose or add other therapy if control worsens.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
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