Drug interactions
Lopinavir + Nifedipine
Severity: Moderate
Lopinavir and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir boosted with ritonavir inhibits CYP3A4 and can raise nifedipine levels, causing hypotension, flushing and edema. The reverse effect of nifedipine on lopinavir is not clinically important.
What this interaction means in plain words
Lopinavir and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lopinavir belongs to Anti Virals; Nifedipine belongs to Cardiovascular.
Why it happens
Ritonavir-boosted lopinavir inhibits CYP3A4, decreasing nifedipine metabolism.
What to do
Begin nifedipine at a low dose and titrate with blood pressure and heart rate monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Nifedipine?
MediHelp rates the interaction as moderate. Lopinavir and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir boosted with ritonavir inhibits CYP3A4 and can raise nifedipine levels, causing hypotension, flushing and edema. The reverse effect of nifedipine on lopinavir is not clinically important.
How serious is the interaction between Lopinavir and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Begin nifedipine at a low dose and titrate with blood pressure and heart rate monitoring.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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