Drug interactions
Lopinavir + Praziquantel
Severity: Moderate
Lopinavir and Praziquantel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir is co-formulated with ritonavir, a strong CYP3A4 inhibitor, and may increase praziquantel exposure. This can intensify dizziness, drowsiness and gastrointestinal symptoms.
What this interaction means in plain words
Lopinavir and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lopinavir belongs to Anti Virals; Praziquantel belongs to Anti Parasitic.
Why it happens
Ritonavir-boosted lopinavir inhibits CYP3A4 metabolism of praziquantel.
What to do
Monitor for praziquantel adverse effects and counsel about sedation and driving. No empiric dose change is generally required for a short course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Praziquantel?
MediHelp rates the interaction as moderate. Lopinavir and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir is co-formulated with ritonavir, a strong CYP3A4 inhibitor, and may increase praziquantel exposure. This can intensify dizziness, drowsiness and gastrointestinal symptoms.
How serious is the interaction between Lopinavir and Praziquantel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for praziquantel adverse effects and counsel about sedation and driving. No empiric dose change is generally required for a short course.
What other medicines interact with Praziquantel?
MediHelp also lists interactions of Praziquantel with, for example, Enzalutamide, Rifampin, Amobarbital. The full list is on the Praziquantel page.
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