Drug interactions
Lopinavir + Sorafenib
Severity: Moderate
Lopinavir and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir, boosted with ritonavir, inhibits CYP3A4 and may raise sorafenib concentrations. Because sorafenib is also cleared through UGT1A9, the effect is probably modest.
What this interaction means in plain words
Lopinavir and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lopinavir belongs to Anti Virals; Sorafenib belongs to Oncology.
Why it happens
CYP3A4 inhibition by ritonavir-boosted lopinavir reduces sorafenib metabolism.
What to do
Monitor for sorafenib adverse effects, including skin toxicity, hypertension and diarrhea. Reduce the dose if toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Sorafenib?
MediHelp rates the interaction as moderate. Lopinavir and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir, boosted with ritonavir, inhibits CYP3A4 and may raise sorafenib concentrations. Because sorafenib is also cleared through UGT1A9, the effect is probably modest.
How serious is the interaction between Lopinavir and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sorafenib adverse effects, including skin toxicity, hypertension and diarrhea. Reduce the dose if toxicity emerges.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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