Drug interactions
Lopinavir + Timolol
Severity: Moderate
Lopinavir and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir, given with ritonavir, may inhibit CYP2D6 and raise timolol exposure, with possible bradycardia, hypotension or conduction effects. Lopinavir itself can prolong PR interval, which adds to the risk of AV block.
What this interaction means in plain words
Lopinavir and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lopinavir belongs to Anti Virals; Timolol belongs to Cardiovascular.
Why it happens
Inhibition of CYP2D6-mediated timolol metabolism combined with additive effects on AV conduction.
What to do
Monitor heart rate, blood pressure and ECG, particularly PR interval, and lower the timolol dose if bradycardia or conduction delay occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Timolol?
MediHelp rates the interaction as moderate. Lopinavir and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir, given with ritonavir, may inhibit CYP2D6 and raise timolol exposure, with possible bradycardia, hypotension or conduction effects. Lopinavir itself can prolong PR interval, which adds to the risk of AV block.
How serious is the interaction between Lopinavir and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG, particularly PR interval, and lower the timolol dose if bradycardia or conduction delay occurs.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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