Drug interactions
Lopinavir + Triptorelin
Severity: Moderate
Lopinavir and Triptorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir/ritonavir can prolong QT and PR intervals, and triptorelin may add to QT prolongation through androgen deprivation. The combination may increase the risk of torsades de pointes.
What this interaction means in plain words
Lopinavir and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lopinavir belongs to Anti Virals; Triptorelin belongs to Endocrine.
Why it happens
Additive QT prolongation.
What to do
Obtain a baseline ECG and correct electrolytes. Monitor ECG periodically, and consider an alternative antiretroviral if QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triptorelin
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Lopinavir with Triptorelin?
MediHelp rates the interaction as moderate. Lopinavir and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir/ritonavir can prolong QT and PR intervals, and triptorelin may add to QT prolongation through androgen deprivation. The combination may increase the risk of torsades de pointes.
How serious is the interaction between Lopinavir and Triptorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolytes. Monitor ECG periodically, and consider an alternative antiretroviral if QTc becomes prolonged.
What other medicines interact with Triptorelin?
MediHelp also lists interactions of Triptorelin with, for example, Amisulpride, Arsenic trioxide, Bedaquiline. The full list is on the Triptorelin page.
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