Drug interactions
Loratadine + Miconazole
Severity: Minor
Loratadine and Miconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loratadine is metabolized by CYP3A4 and CYP2D6, and azole inhibitors can raise its levels. Loratadine has a wide safety margin, so the clinical effect is generally insignificant. Mild sedation or palpitations are possible but unlikely.
What this interaction means in plain words
Loratadine and Miconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Loratadine belongs to Respiratory; Miconazole belongs to Anti Fungals.
Why it happens
Miconazole inhibits CYP3A4, modestly decreasing loratadine metabolism.
What to do
No dose adjustment is required. Advise the patient to report unusual drowsiness or palpitations.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Miconazole
Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Frequently asked questions
Can I take Loratadine with Miconazole?
MediHelp rates the interaction as minor. Loratadine and Miconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Loratadine is metabolized by CYP3A4 and CYP2D6, and azole inhibitors can raise its levels. Loratadine has a wide safety margin, so the clinical effect is generally insignificant. Mild sedation or palpitations are possible but unlikely.
How serious is the interaction between Loratadine and Miconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Advise the patient to report unusual drowsiness or palpitations.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.
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