Drug interactions
Loratadine + Phenelzine
Severity: Minor
Loratadine and Phenelzine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors may prolong and intensify the anticholinergic and sedative effects of antihistamines. Loratadine is a second-generation agent with little anticholinergic or sedative activity, so the interaction is expected to be minor.
What this interaction means in plain words
Loratadine and Phenelzine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Loratadine belongs to Respiratory; Phenelzine belongs to Central Nervous System.
Why it happens
Possible additive CNS and anticholinergic effects; mechanism not firmly established for loratadine.
What to do
Monitor for increased drowsiness, dry mouth or urinary retention. Reduce the dose or switch antihistamine if effects become bothersome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Loratadine with Phenelzine?
MediHelp rates the interaction as minor. Loratadine and Phenelzine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. MAO inhibitors may prolong and intensify the anticholinergic and sedative effects of antihistamines. Loratadine is a second-generation agent with little anticholinergic or sedative activity, so the interaction is expected to be minor.
How serious is the interaction between Loratadine and Phenelzine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased drowsiness, dry mouth or urinary retention. Reduce the dose or switch antihistamine if effects become bothersome.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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