Drug interactions
Loratadine + Vincristine
Severity: Minor
Loratadine and Vincristine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vincristine is a P-glycoprotein substrate, and loratadine may weakly inhibit this transporter. Higher vincristine exposure is theoretically possible, which could worsen neurotoxicity, but this has not been demonstrated.
What this interaction means in plain words
Loratadine and Vincristine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Loratadine belongs to Respiratory; Vincristine belongs to Oncology.
Why it happens
Possible P-glycoprotein inhibition by loratadine reduces vincristine efflux.
What to do
Monitor for peripheral neuropathy and constipation as part of routine vincristine care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Frequently asked questions
Can I take Loratadine with Vincristine?
MediHelp rates the interaction as minor. Loratadine and Vincristine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vincristine is a P-glycoprotein substrate, and loratadine may weakly inhibit this transporter. Higher vincristine exposure is theoretically possible, which could worsen neurotoxicity, but this has not been demonstrated.
How serious is the interaction between Loratadine and Vincristine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for peripheral neuropathy and constipation as part of routine vincristine care.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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