Drug interactions
Lorazepam + Melatonin
Severity: Minor
Lorazepam and Melatonin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin has mild sedative effects and may modestly add to the drowsiness caused by lorazepam. The effect is usually small.
What this interaction means in plain words
Lorazepam and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lorazepam belongs to Central Nervous System; Melatonin belongs to Gastrointestinal Tract.
Why it happens
Additive mild CNS depressant effects via melatonin receptor activity; no significant pharmacokinetic interaction is established.
What to do
No dose change is usually needed. Advise patients to watch for added daytime drowsiness and avoid driving if impaired.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lorazepam
Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Lorazepam with Melatonin?
MediHelp rates the interaction as minor. Lorazepam and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Melatonin has mild sedative effects and may modestly add to the drowsiness caused by lorazepam. The effect is usually small.
How serious is the interaction between Lorazepam and Melatonin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Advise patients to watch for added daytime drowsiness and avoid driving if impaired.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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