Drug interactions
Lorazepam + Midodrine
Severity: Minor
Lorazepam and Midodrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midodrine is a peripheral alpha-1 agonist used for orthostatic hypotension and has no meaningful CNS effects. No clinically important interaction with lorazepam is expected.
What this interaction means in plain words
Lorazepam and Midodrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lorazepam belongs to Central Nervous System; Midodrine belongs to Miscellaneous.
Why it happens
No established mechanism; midodrine acts peripherally and does not significantly affect CNS sedation.
What to do
No specific action is needed. Monitor blood pressure as would be done for either drug alone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lorazepam
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Lorazepam with Midodrine?
MediHelp rates the interaction as minor. Lorazepam and Midodrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Midodrine is a peripheral alpha-1 agonist used for orthostatic hypotension and has no meaningful CNS effects. No clinically important interaction with lorazepam is expected.
How serious is the interaction between Lorazepam and Midodrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed. Monitor blood pressure as would be done for either drug alone.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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