Drug interactions
Lorazepam + Mirtazapine
Severity: Moderate
Lorazepam and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirtazapine is a sedating antidepressant, and with lorazepam it increases drowsiness and impairs psychomotor performance. The effect is most noticeable at the start of treatment and with lower mirtazapine doses.
What this interaction means in plain words
Lorazepam and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorazepam belongs to Central Nervous System; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and strong H1 antagonism by mirtazapine.
What to do
Monitor for excessive sedation, particularly in older patients, and counsel on driving and alcohol. Give mirtazapine at bedtime and reduce doses if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Lorazepam with Mirtazapine?
MediHelp rates the interaction as moderate. Lorazepam and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mirtazapine is a sedating antidepressant, and with lorazepam it increases drowsiness and impairs psychomotor performance. The effect is most noticeable at the start of treatment and with lower mirtazapine doses.
How serious is the interaction between Lorazepam and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, particularly in older patients, and counsel on driving and alcohol. Give mirtazapine at bedtime and reduce doses if needed.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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