Drug interactions
Lorazepam + Modafinil
Severity: Minor
Lorazepam and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil promotes wakefulness and may partly counteract sedation from lorazepam. Modafinil may also modestly induce CYP3A4, but lorazepam is cleared by glucuronidation so little change in exposure is expected.
What this interaction means in plain words
Lorazepam and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lorazepam belongs to Central Nervous System; Modafinil belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects on arousal; lorazepam is metabolized by glucuronidation, so no important pharmacokinetic interaction is expected.
What to do
No routine adjustment is needed. Monitor therapeutic response to both drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lorazepam
Other interactions of Modafinil
Frequently asked questions
Can I take Lorazepam with Modafinil?
MediHelp rates the interaction as minor. Lorazepam and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Modafinil promotes wakefulness and may partly counteract sedation from lorazepam. Modafinil may also modestly induce CYP3A4, but lorazepam is cleared by glucuronidation so little change in exposure is expected.
How serious is the interaction between Lorazepam and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor therapeutic response to both drugs.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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