Drug interactions

Lorazepam + Pregabalin

Severity: Major

Lorazepam and Pregabalin: major interaction.

Last updated 29 Oct 2026 Sources: US FDA label

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Pregabalin added to lorazepam increases sedation, dizziness and cognitive and motor impairment. Respiratory depression is possible, notably in older or respiratory-compromised patients.

What this interaction means in plain words

Lorazepam and Pregabalin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Lorazepam belongs to Central Nervous System; Pregabalin belongs to Central Nervous System.

Evidence level: Moderate

Why it happens

Additive pharmacodynamic CNS depression.

What to do

Use the lowest effective doses of each and monitor for oversedation and breathing problems, especially during titration. Counsel on driving and alcohol.

What to ask your pharmacist

Does the benefit of taking both outweigh the risk in my case?
Do I need any blood test, ECG or other check while on both?
What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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References

PREGABALIN - FDA drug label (DailyMed) - section 7 Drug Interactions (names the partner; "used antiepileptic drugs [see Clinical Pharmacology (12) ] . Pharmacodynamics Multiple oral doses of pregabalin were co-administered with oxycodone, lorazepam, ") — DailyMed (FDA label)

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Brexanolone + Pregabalin Major
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Frequently asked questions

Can I take Lorazepam with Pregabalin?

MediHelp rates the interaction as major. Lorazepam and Pregabalin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pregabalin added to lorazepam increases sedation, dizziness and cognitive and motor impairment. Respiratory depression is possible, notably in older or respiratory-compromised patients.

How serious is the interaction between Lorazepam and Pregabalin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses of each and monitor for oversedation and breathing problems, especially during titration. Counsel on driving and alcohol.

What other medicines interact with Lorazepam?

MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.

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