Drug interactions
Lorazepam + Risperidone
Severity: Moderate
Lorazepam and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taken together, these drugs can increase drowsiness, dizziness and psychomotor impairment. Risperidone may also lower blood pressure on standing, adding to fall risk.
What this interaction means in plain words
Lorazepam and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorazepam belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression and alpha-1 adrenergic blockade.
What to do
Monitor sedation and orthostatic blood pressure, especially during dose changes and in older patients. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Lorazepam with Risperidone?
MediHelp rates the interaction as moderate. Lorazepam and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Taken together, these drugs can increase drowsiness, dizziness and psychomotor impairment. Risperidone may also lower blood pressure on standing, adding to fall risk.
How serious is the interaction between Lorazepam and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and orthostatic blood pressure, especially during dose changes and in older patients. Use the lowest effective doses.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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