Drug interactions
Lorazepam + Sevoflurane
Severity: Moderate
Lorazepam and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Premedication with lorazepam lowers the sevoflurane concentration needed for anesthesia, and together they can deepen sedation and respiratory depression. Recovery may be slower, with prolonged drowsiness after surgery.
What this interaction means in plain words
Lorazepam and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorazepam belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive GABA-A mediated CNS depression.
What to do
Titrate the volatile anesthetic to effect with standard anesthetic monitoring, and anticipate lower requirements. Monitor recovery and respiratory function postoperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Sevoflurane
Frequently asked questions
Can I take Lorazepam with Sevoflurane?
MediHelp rates the interaction as moderate. Lorazepam and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Premedication with lorazepam lowers the sevoflurane concentration needed for anesthesia, and together they can deepen sedation and respiratory depression. Recovery may be slower, with prolonged drowsiness after surgery.
How serious is the interaction between Lorazepam and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate the volatile anesthetic to effect with standard anesthetic monitoring, and anticipate lower requirements. Monitor recovery and respiratory function postoperatively.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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