Drug interactions
Lorazepam + Stiripentol
Severity: Moderate
Lorazepam and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol causes somnolence and, combined with a benzodiazepine such as lorazepam, can add to sedation and psychomotor impairment. Daytime drowsiness, reduced alertness and impaired driving ability may become more pronounced.
What this interaction means in plain words
Lorazepam and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorazepam belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Additive central nervous system depression via GABAergic enhancement by both agents.
What to do
Monitor for excessive sedation, especially at initiation or dose increases, and reduce the lorazepam dose if drowsiness is troublesome. Counsel patients to avoid alcohol and driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Stiripentol
Frequently asked questions
Can I take Lorazepam with Stiripentol?
MediHelp rates the interaction as moderate. Lorazepam and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol causes somnolence and, combined with a benzodiazepine such as lorazepam, can add to sedation and psychomotor impairment. Daytime drowsiness, reduced alertness and impaired driving ability may become more pronounced.
How serious is the interaction between Lorazepam and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, especially at initiation or dose increases, and reduce the lorazepam dose if drowsiness is troublesome. Counsel patients to avoid alcohol and driving until the response is known.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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