Drug interactions
Lorazepam + Trazodone
Severity: Moderate
Lorazepam and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating, and together they can cause marked drowsiness, dizziness and impaired psychomotor performance. Orthostatic hypotension from trazodone may increase fall risk, especially in older patients.
What this interaction means in plain words
Lorazepam and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorazepam belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and trazodone's antihistaminic and alpha-1 blocking activity.
What to do
Start with low doses and monitor sedation and orthostatic blood pressure. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Lorazepam with Trazodone?
MediHelp rates the interaction as moderate. Lorazepam and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating, and together they can cause marked drowsiness, dizziness and impaired psychomotor performance. Orthostatic hypotension from trazodone may increase fall risk, especially in older patients.
How serious is the interaction between Lorazepam and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and monitor sedation and orthostatic blood pressure. Advise patients to avoid driving and alcohol.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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