Drug interactions
Lorazepam + Trimipramine
Severity: Moderate
Lorazepam and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine is a strongly sedating tricyclic antidepressant, and with lorazepam it can cause additive drowsiness, psychomotor impairment and hypotension. Anticholinergic effects may add to confusion in older adults.
What this interaction means in plain words
Lorazepam and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorazepam belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation and trimipramine's antihistaminic, anticholinergic and alpha-blocking effects.
What to do
Use the lowest effective doses and monitor sedation, cognition and orthostatic blood pressure. Take particular care in older patients and counsel on driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Lorazepam with Trimipramine?
MediHelp rates the interaction as moderate. Lorazepam and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimipramine is a strongly sedating tricyclic antidepressant, and with lorazepam it can cause additive drowsiness, psychomotor impairment and hypotension. Anticholinergic effects may add to confusion in older adults.
How serious is the interaction between Lorazepam and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation, cognition and orthostatic blood pressure. Take particular care in older patients and counsel on driving.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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