Drug interactions
Lorcaserin + Metoclopramide
Severity: Moderate
Lorcaserin and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide is cleared mainly through CYP2D6, and inhibition of this enzyme raises its exposure. Higher levels increase the risk of extrapyramidal symptoms, tardive dyskinesia and sedation. Lorcaserin is a weak CYP2D6 inhibitor and also has serotonergic activity, so the effect is modest.
What this interaction means in plain words
Lorcaserin and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP2D6 inhibition by lorcaserin reduces metoclopramide metabolism, with possible additive serotonergic and dopaminergic adverse effects.
What to do
Monitor for extrapyramidal symptoms, restlessness and sedation, and lower the metoclopramide dose if they appear. Keep the metoclopramide course short.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lorcaserin and Metoclopramide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metoclopramide
Frequently asked questions
Can I take Lorcaserin with Metoclopramide?
MediHelp rates the interaction as moderate. Lorcaserin and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide is cleared mainly through CYP2D6, and inhibition of this enzyme raises its exposure. Higher levels increase the risk of extrapyramidal symptoms, tardive dyskinesia and sedation. Lorcaserin is a weak CYP2D6 inhibitor and also has serotonergic activity, so the effect is modest.
How serious is the interaction between Lorcaserin and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, restlessness and sedation, and lower the metoclopramide dose if they appear. Keep the metoclopramide course short.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
