Drug interactions
Lorlatinib + Omaveloxolone
Severity: Moderate
Lorlatinib and Omaveloxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib may reduce omaveloxolone exposure by inducing CYP3A4, potentially decreasing treatment benefit in Friedreich ataxia.
What this interaction means in plain words
Lorlatinib and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Omaveloxolone belongs to Central Nervous System.
Why it happens
CYP3A4 induction increases omaveloxolone metabolism.
What to do
Monitor clinical response and consider alternatives if effect is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Lorlatinib with Omaveloxolone?
MediHelp rates the interaction as moderate. Lorlatinib and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib may reduce omaveloxolone exposure by inducing CYP3A4, potentially decreasing treatment benefit in Friedreich ataxia.
How serious is the interaction between Lorlatinib and Omaveloxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and consider alternatives if effect is lost.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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