Drug interactions
Lorlatinib + Oxycodone
Severity: Moderate
Lorlatinib and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib is a moderate CYP3A inducer and may lower oxycodone exposure, potentially reducing analgesia. If lorlatinib is stopped, oxycodone levels may rise again and increase opioid adverse effects.
What this interaction means in plain words
Lorlatinib and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Oxycodone belongs to Musculoskeletal.
Why it happens
Lorlatinib induces CYP3A4, increasing oxycodone's metabolism to noroxycodone.
What to do
Monitor pain control and titrate the oxycodone dose upward if needed. Reassess for sedation and respiratory depression when lorlatinib is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Lorlatinib with Oxycodone?
MediHelp rates the interaction as moderate. Lorlatinib and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib is a moderate CYP3A inducer and may lower oxycodone exposure, potentially reducing analgesia. If lorlatinib is stopped, oxycodone levels may rise again and increase opioid adverse effects.
How serious is the interaction between Lorlatinib and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and titrate the oxycodone dose upward if needed. Reassess for sedation and respiratory depression when lorlatinib is discontinued.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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