Drug interactions
Lorlatinib + Panobinostat
Severity: Moderate
Lorlatinib and Panobinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Panobinostat is partly metabolized by CYP3A4, so lorlatinib may lower its exposure and efficacy.
What this interaction means in plain words
Lorlatinib and Panobinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Panobinostat belongs to Oncology.
Why it happens
Lorlatinib induces CYP3A4, increasing panobinostat clearance.
What to do
Monitor myeloma response. Consider alternatives to lorlatinib if efficacy appears reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
Frequently asked questions
Can I take Lorlatinib with Panobinostat?
MediHelp rates the interaction as moderate. Lorlatinib and Panobinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Panobinostat is partly metabolized by CYP3A4, so lorlatinib may lower its exposure and efficacy.
How serious is the interaction between Lorlatinib and Panobinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor myeloma response. Consider alternatives to lorlatinib if efficacy appears reduced.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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