Drug interactions
Lorlatinib + Trazodone
Severity: Moderate
Lorlatinib and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib is a moderate inducer of CYP3A4, and trazodone is cleared mainly through CYP3A4. Exposure to trazodone may fall, which can reduce its antidepressant or hypnotic effect.
What this interaction means in plain words
Lorlatinib and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Trazodone belongs to Central Nervous System.
Why it happens
Lorlatinib induces CYP3A4, increasing trazodone metabolism and lowering plasma levels.
What to do
Monitor for loss of antidepressant or sleep benefit and titrate the trazodone dose upward if needed. Reassess the dose if lorlatinib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Lorlatinib with Trazodone?
MediHelp rates the interaction as moderate. Lorlatinib and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib is a moderate inducer of CYP3A4, and trazodone is cleared mainly through CYP3A4. Exposure to trazodone may fall, which can reduce its antidepressant or hypnotic effect.
How serious is the interaction between Lorlatinib and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of antidepressant or sleep benefit and titrate the trazodone dose upward if needed. Reassess the dose if lorlatinib is stopped.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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