Drug interactions
Lorlatinib + Valbenazine
Severity: Moderate
Lorlatinib and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib may lower exposure to valbenazine and its active metabolite. Reduced control of tardive dyskinesia may result.
What this interaction means in plain words
Lorlatinib and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lorlatinib belongs to Oncology; Valbenazine belongs to Central Nervous System.
Why it happens
Lorlatinib induces CYP3A4, increasing the metabolism of valbenazine and its active metabolite.
What to do
Monitor for loss of symptom control and consider an alternative to valbenazine if response declines. Strong inducers are not recommended with valbenazine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Lorlatinib with Valbenazine?
MediHelp rates the interaction as moderate. Lorlatinib and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib may lower exposure to valbenazine and its active metabolite. Reduced control of tardive dyskinesia may result.
How serious is the interaction between Lorlatinib and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of symptom control and consider an alternative to valbenazine if response declines. Strong inducers are not recommended with valbenazine.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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