Drug interactions
Lorlatinib + Vortioxetine
Severity: Minor
Lorlatinib and Vortioxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib is a moderate CYP3A inducer and may reduce vortioxetine exposure, which could weaken antidepressant response. Vortioxetine is cleared mainly via CYP2D6 with minor CYP3A contribution, so the effect is likely limited.
What this interaction means in plain words
Lorlatinib and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lorlatinib belongs to Oncology; Vortioxetine belongs to Central Nervous System.
Why it happens
Lorlatinib induces CYP3A4, modestly increasing vortioxetine metabolism.
What to do
Monitor for loss of antidepressant effect and adjust the vortioxetine dose if relapse symptoms appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Lorlatinib with Vortioxetine?
MediHelp rates the interaction as minor. Lorlatinib and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lorlatinib is a moderate CYP3A inducer and may reduce vortioxetine exposure, which could weaken antidepressant response. Vortioxetine is cleared mainly via CYP2D6 with minor CYP3A contribution, so the effect is likely limited.
How serious is the interaction between Lorlatinib and Vortioxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of antidepressant effect and adjust the vortioxetine dose if relapse symptoms appear.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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