Drug interactions
Lormetazepam + Propofol
Severity: Moderate
Lormetazepam and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol given with lormetazepam leads to additive sedation and respiratory depression. Deeper than intended sedation, hypotension and apnea may occur, particularly in elderly or frail patients.
What this interaction means in plain words
Lormetazepam and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Both agents potentiate GABA-A receptor mediated inhibition, producing additive CNS and respiratory depression.
What to do
Lower the propofol dose and titrate carefully while monitoring respiratory rate, oxygen saturation and blood pressure. Have airway support available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lormetazepam and Propofol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Propofol
Frequently asked questions
Can I take Lormetazepam with Propofol?
MediHelp rates the interaction as moderate. Lormetazepam and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propofol given with lormetazepam leads to additive sedation and respiratory depression. Deeper than intended sedation, hypotension and apnea may occur, particularly in elderly or frail patients.
How serious is the interaction between Lormetazepam and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Lower the propofol dose and titrate carefully while monitoring respiratory rate, oxygen saturation and blood pressure. Have airway support available.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
