Drug interactions
Lornoxicam + Nebivolol
Severity: Moderate
Lornoxicam and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as lornoxicam can reduce the antihypertensive effect of beta-blockers through sodium and water retention and prostaglandin inhibition. This is most relevant with regular use over more than a week, and renal function may also be affected.
What this interaction means in plain words
Lornoxicam and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lornoxicam belongs to Musculoskeletal; Nebivolol belongs to Cardiovascular.
Why it happens
Inhibition of vasodilatory prostaglandins causes fluid retention and attenuates the antihypertensive effect.
What to do
Monitor blood pressure when NSAIDs are used regularly and use the lowest effective dose for the shortest time. Consider paracetamol or another alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Lornoxicam with Nebivolol?
MediHelp rates the interaction as moderate. Lornoxicam and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as lornoxicam can reduce the antihypertensive effect of beta-blockers through sodium and water retention and prostaglandin inhibition. This is most relevant with regular use over more than a week, and renal function may also be affected.
How serious is the interaction between Lornoxicam and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when NSAIDs are used regularly and use the lowest effective dose for the shortest time. Consider paracetamol or another alternative.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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