Drug interactions
Lornoxicam + Sertraline
Severity: Major
Lornoxicam and Sertraline: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs reduce platelet serotonin and NSAIDs such as lornoxicam impair platelet function and irritate the gastric mucosa. Together they substantially raise the risk of gastrointestinal bleeding.
What this interaction means in plain words
Lornoxicam and Sertraline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lornoxicam belongs to Musculoskeletal; Sertraline belongs to Central Nervous System.
Why it happens
Additive impairment of platelet aggregation combined with NSAID-induced mucosal injury.
What to do
Avoid the combination where possible or use the shortest NSAID course at the lowest dose with a proton pump inhibitor. Counsel patients to report black stools or hematemesis.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Lornoxicam
Frequently asked questions
Can I take Lornoxicam with Sertraline?
MediHelp rates the interaction as major. Lornoxicam and Sertraline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. SSRIs reduce platelet serotonin and NSAIDs such as lornoxicam impair platelet function and irritate the gastric mucosa. Together they substantially raise the risk of gastrointestinal bleeding.
How serious is the interaction between Lornoxicam and Sertraline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible or use the shortest NSAID course at the lowest dose with a proton pump inhibitor. Counsel patients to report black stools or hematemesis.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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