Drug interactions
Lornoxicam + Tolazamide
Severity: Moderate
Lornoxicam and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as lornoxicam may potentiate sulfonylurea effects, leading to hypoglycemia in some patients. Evidence comes largely from other NSAIDs and the effect is variable.
What this interaction means in plain words
Lornoxicam and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lornoxicam belongs to Musculoskeletal; Tolazamide belongs to Endocrine.
Why it happens
Possible protein-binding displacement and altered renal prostaglandin effects; the mechanism is not firmly established for lornoxicam.
What to do
Monitor blood glucose when starting or stopping lornoxicam and adjust the tolazamide dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lornoxicam and Tolazamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Other interactions of Lornoxicam
Frequently asked questions
Can I take Lornoxicam with Tolazamide?
MediHelp rates the interaction as moderate. Lornoxicam and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as lornoxicam may potentiate sulfonylurea effects, leading to hypoglycemia in some patients. Evidence comes largely from other NSAIDs and the effect is variable.
How serious is the interaction between Lornoxicam and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping lornoxicam and adjust the tolazamide dose if needed.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
