Drug interactions
Lornoxicam + Tolbutamide
Severity: Moderate
Lornoxicam and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lornoxicam is a CYP2C9 substrate and NSAIDs may potentiate sulfonylurea effects, increasing the risk of hypoglycemia with tolbutamide.
What this interaction means in plain words
Lornoxicam and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lornoxicam belongs to Musculoskeletal; Tolbutamide belongs to Endocrine.
Why it happens
Possible competition at CYP2C9 and protein binding displacement; mechanism not firmly established.
What to do
Monitor blood glucose when starting or stopping lornoxicam and reduce the tolbutamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Other interactions of Lornoxicam
Frequently asked questions
Can I take Lornoxicam with Tolbutamide?
MediHelp rates the interaction as moderate. Lornoxicam and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lornoxicam is a CYP2C9 substrate and NSAIDs may potentiate sulfonylurea effects, increasing the risk of hypoglycemia with tolbutamide.
How serious is the interaction between Lornoxicam and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping lornoxicam and reduce the tolbutamide dose if hypoglycemia occurs.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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