Drug interactions
Lornoxicam + Vancomycin
Severity: Moderate
Lornoxicam and Vancomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can lower renal perfusion and glomerular filtration, which may increase vancomycin concentrations and nephrotoxicity risk. The effect is best described in neonates given NSAIDs.
What this interaction means in plain words
Lornoxicam and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lornoxicam belongs to Musculoskeletal; Vancomycin belongs to Anti Bacterial.
Why it happens
NSAID-induced renal vasoconstriction reduces vancomycin renal clearance.
What to do
Monitor serum creatinine and vancomycin levels, and adjust the dose as needed. Avoid NSAIDs in patients with renal impairment or volume depletion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Lornoxicam with Vancomycin?
MediHelp rates the interaction as moderate. Lornoxicam and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can lower renal perfusion and glomerular filtration, which may increase vancomycin concentrations and nephrotoxicity risk. The effect is best described in neonates given NSAIDs.
How serious is the interaction between Lornoxicam and Vancomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and vancomycin levels, and adjust the dose as needed. Avoid NSAIDs in patients with renal impairment or volume depletion.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Capreomycin. The full list is on the Vancomycin page.
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