Drug interactions
Losartan + Mifepristone
Severity: Minor
Losartan and Mifepristone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4, which could alter losartan metabolism. Losartan is metabolized mainly by CYP2C9 and CYP3A4, so any effect is expected to be small and clinical relevance is uncertain.
What this interaction means in plain words
Losartan and Mifepristone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Losartan belongs to Cardiovascular; Mifepristone belongs to Endocrine.
Why it happens
Mifepristone inhibition of CYP3A4 may slightly reduce conversion of losartan to its active metabolite or its clearance.
What to do
No routine adjustment is needed; monitor blood pressure if mifepristone is used chronically, as in Cushing syndrome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Losartan with Mifepristone?
MediHelp rates the interaction as minor. Losartan and Mifepristone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mifepristone inhibits CYP3A4, which could alter losartan metabolism. Losartan is metabolized mainly by CYP2C9 and CYP3A4, so any effect is expected to be small and clinical relevance is uncertain.
How serious is the interaction between Losartan and Mifepristone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor blood pressure if mifepristone is used chronically, as in Cushing syndrome.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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