Drug interactions
Losartan + Mitotane
Severity: Moderate
Losartan and Mitotane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong enzyme inducer and can lower plasma concentrations of losartan and its active metabolite, reducing antihypertensive effect. The effect may persist for weeks after mitotane is stopped because of its long half-life.
What this interaction means in plain words
Losartan and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Losartan belongs to Cardiovascular; Mitotane belongs to Oncology.
Why it happens
Induction of CYP3A4 and other CYP enzymes involved in losartan metabolism.
What to do
Monitor blood pressure and increase the losartan dose if needed, or consider another antihypertensive class; reassess when mitotane is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Losartan with Mitotane?
MediHelp rates the interaction as moderate. Losartan and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a strong enzyme inducer and can lower plasma concentrations of losartan and its active metabolite, reducing antihypertensive effect. The effect may persist for weeks after mitotane is stopped because of its long half-life.
How serious is the interaction between Losartan and Mitotane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and increase the losartan dose if needed, or consider another antihypertensive class; reassess when mitotane is withdrawn.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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