Drug interactions
Losartan + Nadolol
Severity: Moderate
Losartan and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure and combining them is common practice, with additive hypotension possible. Beta blockers can also reduce renin-mediated potassium handling slightly, and losartan raises potassium, so hyperkalemia is possible in susceptible patients. Losartan is also fetotoxic in pregnancy.
What this interaction means in plain words
Losartan and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Losartan belongs to Cardiovascular; Nadolol belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering through beta blockade and angiotensin receptor blockade, with a minor additive effect on potassium retention.
What to do
Monitor blood pressure, heart rate and serum potassium, particularly in renal impairment or diabetes, and avoid use in pregnancy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Nadolol
Frequently asked questions
Can I take Losartan with Nadolol?
MediHelp rates the interaction as moderate. Losartan and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure and combining them is common practice, with additive hypotension possible. Beta blockers can also reduce renin-mediated potassium handling slightly, and losartan raises potassium, so hyperkalemia is possible in susceptible patients. Losartan is also fetotoxic in pregnancy.
How serious is the interaction between Losartan and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and serum potassium, particularly in renal impairment or diabetes, and avoid use in pregnancy.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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