Drug interactions
Losartan + Nebivolol
Severity: Moderate
Losartan and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Together they produce additive blood pressure reduction, which can cause hypotension, particularly at initiation. Losartan may raise serum potassium and is contraindicated in pregnancy.
What this interaction means in plain words
Losartan and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Losartan belongs to Cardiovascular; Nebivolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects; angiotensin receptor blockade reduces aldosterone-mediated potassium excretion.
What to do
Monitor blood pressure, potassium and renal function when starting or changing doses. Adjust doses if hypotension or hyperkalemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Losartan with Nebivolol?
MediHelp rates the interaction as moderate. Losartan and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Together they produce additive blood pressure reduction, which can cause hypotension, particularly at initiation. Losartan may raise serum potassium and is contraindicated in pregnancy.
How serious is the interaction between Losartan and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, potassium and renal function when starting or changing doses. Adjust doses if hypotension or hyperkalemia occurs.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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