Drug interactions
Losartan + Paclitaxel
Severity: Minor
Losartan and Paclitaxel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel is cleared by CYP2C8 and CYP3A4. Losartan has only weak or insignificant CYP2C8 inhibition, so a clinically meaningful rise in paclitaxel exposure is unlikely.
What this interaction means in plain words
Losartan and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Losartan belongs to Cardiovascular; Paclitaxel belongs to Oncology.
Why it happens
Theoretical weak CYP2C8 inhibition by losartan or its metabolite reducing paclitaxel clearance.
What to do
No adjustment is needed; monitor for paclitaxel toxicity such as neutropenia and neuropathy as per routine care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Paclitaxel
Frequently asked questions
Can I take Losartan with Paclitaxel?
MediHelp rates the interaction as minor. Losartan and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Paclitaxel is cleared by CYP2C8 and CYP3A4. Losartan has only weak or insignificant CYP2C8 inhibition, so a clinically meaningful rise in paclitaxel exposure is unlikely.
How serious is the interaction between Losartan and Paclitaxel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed; monitor for paclitaxel toxicity such as neutropenia and neuropathy as per routine care.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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