Drug interactions
Losartan + Secobarbital
Severity: Minor
Losartan and Secobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital is an enzyme inducer and may lower plasma levels of losartan and its active metabolite. This could weaken blood pressure control.
What this interaction means in plain words
Losartan and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Losartan belongs to Cardiovascular; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturate induction of CYP2C9 and CYP3A4 increases losartan metabolism.
What to do
Monitor blood pressure when secobarbital is started or stopped and titrate losartan as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Losartan with Secobarbital?
MediHelp rates the interaction as minor. Losartan and Secobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Secobarbital is an enzyme inducer and may lower plasma levels of losartan and its active metabolite. This could weaken blood pressure control.
How serious is the interaction between Losartan and Secobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when secobarbital is started or stopped and titrate losartan as needed.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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