Drug interactions
Losartan + Sulindac
Severity: Moderate
Losartan and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the antihypertensive effect of losartan and the combination may cause acute kidney injury and hyperkalemia, especially in older or volume-depleted patients.
What this interaction means in plain words
Losartan and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Losartan belongs to Cardiovascular; Sulindac belongs to Musculoskeletal.
Why it happens
NSAID blockade of vasodilatory renal prostaglandins combined with ARB reduction of efferent arteriolar tone lowers glomerular filtration and promotes potassium retention.
What to do
Monitor blood pressure, serum creatinine and potassium after starting co-therapy and maintain hydration. Avoid in dehydrated patients or those with advanced kidney disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Losartan with Sulindac?
MediHelp rates the interaction as moderate. Losartan and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the antihypertensive effect of losartan and the combination may cause acute kidney injury and hyperkalemia, especially in older or volume-depleted patients.
How serious is the interaction between Losartan and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after starting co-therapy and maintain hydration. Avoid in dehydrated patients or those with advanced kidney disease.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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