Drug interactions
Losartan + Tolfenamic acid
Severity: Moderate
Losartan and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolfenamic acid, an NSAID, can blunt the antihypertensive effect of losartan and reduce renal function, particularly in volume-depleted or elderly patients. Hyperkalemia and acute kidney injury may occur.
What this interaction means in plain words
Losartan and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Losartan belongs to Cardiovascular; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces glomerular perfusion and sodium and potassium excretion in the presence of angiotensin receptor blockade.
What to do
Monitor creatinine, potassium and blood pressure, maintain hydration, and use the shortest NSAID course possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Losartan with Tolfenamic acid?
MediHelp rates the interaction as moderate. Losartan and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolfenamic acid, an NSAID, can blunt the antihypertensive effect of losartan and reduce renal function, particularly in volume-depleted or elderly patients. Hyperkalemia and acute kidney injury may occur.
How serious is the interaction between Losartan and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor creatinine, potassium and blood pressure, maintain hydration, and use the shortest NSAID course possible.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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