Drug interactions
Losartan + Voclosporin
Severity: Major
Losartan and Voclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a calcineurin inhibitor that can cause nephrotoxicity and hyperkalemia, and losartan can add to both through reduced glomerular pressure and aldosterone suppression. Reduced eGFR and elevated potassium may occur.
What this interaction means in plain words
Losartan and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Losartan belongs to Cardiovascular; Voclosporin belongs to Miscellaneous.
Why it happens
Calcineurin inhibitor afferent vasoconstriction and reduced potassium excretion combine with ARB efferent dilation and aldosterone suppression.
What to do
Monitor eGFR and serum potassium frequently, especially during initiation and dose changes. Reduce or interrupt voclosporin per labeling if renal function declines or hyperkalemia develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Losartan with Voclosporin?
MediHelp rates the interaction as major. Losartan and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voclosporin is a calcineurin inhibitor that can cause nephrotoxicity and hyperkalemia, and losartan can add to both through reduced glomerular pressure and aldosterone suppression. Reduced eGFR and elevated potassium may occur.
How serious is the interaction between Losartan and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor eGFR and serum potassium frequently, especially during initiation and dose changes. Reduce or interrupt voclosporin per labeling if renal function declines or hyperkalemia develops.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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