Drug interactions
Losartan + Voxelotor
Severity: Minor
Losartan and Voxelotor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor can inhibit CYP3A4 and may modestly alter losartan metabolism. Losartan is not a narrow therapeutic index CYP3A4 substrate, so the clinical impact is likely small.
What this interaction means in plain words
Losartan and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Losartan belongs to Cardiovascular; Voxelotor belongs to Miscellaneous.
Why it happens
Weak to moderate CYP3A4 inhibition by voxelotor reduces losartan metabolism.
What to do
No routine adjustment; check blood pressure after starting voxelotor.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Losartan with Voxelotor?
MediHelp rates the interaction as minor. Losartan and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voxelotor can inhibit CYP3A4 and may modestly alter losartan metabolism. Losartan is not a narrow therapeutic index CYP3A4 substrate, so the clinical impact is likely small.
How serious is the interaction between Losartan and Voxelotor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; check blood pressure after starting voxelotor.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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