Drug interactions
Lovastatin + Mifepristone
Severity: Contraindicated
Lovastatin and Mifepristone: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and can substantially raise lovastatin exposure, a drug that depends heavily on this enzyme for clearance. Higher lovastatin levels greatly increase the risk of myopathy and rhabdomyolysis.
What this interaction means in plain words
Lovastatin and Mifepristone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lovastatin belongs to Cardiovascular; Mifepristone belongs to Endocrine.
Why it happens
Mifepristone inhibits CYP3A4-mediated first-pass and hepatic metabolism of lovastatin, increasing systemic exposure.
What to do
Do not use together; hold lovastatin or switch to a statin less dependent on CYP3A4, such as pravastatin or rosuvastatin, during mifepristone treatment.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Lovastatin with Mifepristone?
MediHelp rates the interaction as contraindicated. Lovastatin and Mifepristone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mifepristone inhibits CYP3A4 and can substantially raise lovastatin exposure, a drug that depends heavily on this enzyme for clearance. Higher lovastatin levels greatly increase the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Lovastatin and Mifepristone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; hold lovastatin or switch to a statin less dependent on CYP3A4, such as pravastatin or rosuvastatin, during mifepristone treatment.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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