Drug interactions
Lovastatin + Mitotane
Severity: Moderate
Lovastatin and Mitotane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong CYP3A4 inducer and can markedly lower lovastatin concentrations. This may lead to loss of lipid-lowering efficacy.
What this interaction means in plain words
Lovastatin and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lovastatin belongs to Cardiovascular; Mitotane belongs to Oncology.
Why it happens
Mitotane induces CYP3A4, increasing the metabolism of lovastatin.
What to do
Monitor lipid levels and increase the lovastatin dose if needed, or switch to a statin less affected by CYP3A4 induction such as rosuvastatin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Lovastatin with Mitotane?
MediHelp rates the interaction as moderate. Lovastatin and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a strong CYP3A4 inducer and can markedly lower lovastatin concentrations. This may lead to loss of lipid-lowering efficacy.
How serious is the interaction between Lovastatin and Mitotane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lipid levels and increase the lovastatin dose if needed, or switch to a statin less affected by CYP3A4 induction such as rosuvastatin.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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