Drug interactions
Lovastatin + Voclosporin
Severity: Moderate
Lovastatin and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin inhibits OATP1B1 and may increase exposure to statins that rely on hepatic uptake, and it is also a CYP3A4 substrate and inhibitor. This may raise the risk of myopathy with lovastatin.
What this interaction means in plain words
Lovastatin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lovastatin belongs to Cardiovascular; Voclosporin belongs to Miscellaneous.
Why it happens
Inhibition of OATP1B1 and CYP3A4 reduces hepatic uptake and metabolism of lovastatin.
What to do
Use the lowest effective lovastatin dose and monitor for myopathy, or switch to a statin with less transporter and CYP3A4 dependence.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Lovastatin with Voclosporin?
MediHelp rates the interaction as moderate. Lovastatin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin inhibits OATP1B1 and may increase exposure to statins that rely on hepatic uptake, and it is also a CYP3A4 substrate and inhibitor. This may raise the risk of myopathy with lovastatin.
How serious is the interaction between Lovastatin and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective lovastatin dose and monitor for myopathy, or switch to a statin with less transporter and CYP3A4 dependence.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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